i RNA Technology | UPSC
Micro RNAs
- MicroRNAs (miRNAs) are noncoding, single-stranded RNAs, approximately 22 nucleotides in length, that function as negative regulators of genes.
- They inhibit gene expression post transcriptionally by repressing translation or, in some cases, by messenger RNA (mRNA) cleavage.
- In view of their important function to control cell growth, differentiation, and survival, it is not surprising that accumulating evidence supports a role for miRNAs in carcinogenesis.
- Exogenous SiRNAs/Endogenous mRNAs
- Interaction with Argonaute
- RNA induced Complex
- GENE SILENCING
Therapeutic applications
- Antiviral treatment
- Cancer treatment
- Neurodegenerative disease
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