110 high yield topics for UPSC Medical Sciences Optional revision

UPDATED FOR YEAR 2025

Find 110 high-yield topics (based on the latest trend and repeat pattern) to revise for UPSC Medical sciences optional final Examination.

Predictive topics highlighted (P)

Anatomy

1. The facial nerve (Functional components of all cranial nerves)
2. Placenta (P)
3. Development of heart (Including anomalies)
4. Shoulder joint/Hip joint/Knee joint
5. Brachial plexus (Radial Nerve, Ulnar nerve, Median nerve (P), Erbs, and klumpky’s palsy)
6. Anatomy of tongue
7. Autonomic nervous system (Components)
8. Lymphatic drainage of Stomach/Breast
9. Anatomy of Liver (P)
10. Anatomy of Kidney and Prostate

Biochemistry

1. PCR (P)/RFLP/RIA (P)
2. Liver function tests (Approach to jaundice) (P)
3. Vitamins (Vitamin B12, Folic acid, Vitamin A/C/D) – (Focus on Biochemical functions/reactions)
4. Posttranscriptional and Posttranslational modifications
5. Inhibitors of protein synthesis

Physiology

1. Ascending pathways
2. Descending pathways
3. Control of Equilibrium and posture (P)
4. Sleep physiology (P)
5. Cardiac output
6. Erythropoiesis
7. Calcium metabolism
8. Growth hormone
9. Isotonic and Isometric contraction
10. Reflexes

Forensic Medicine

1. Blood and seminal stains
2. OP Poisoning (P)
3. Snake bite management
4. Drug Abuse (P)
5. Antemortem vs Postmortem Wound
6. Grievous hurt
7. Entry and Exit wound
8. DNA Fingerprinting

Microbiology (Including Immunology and Infectious diseases)

1. Immunoglobulins
2. Dengue (P)
3. HIV
4. Rabies (P)
5. Amoebic vs Bacillary dysentery
6. Candida
7. Giardia

Pathology

1. Chronic/Granulomatouss inflammation
2. Benign vs malignant neoplasm
3. CML (P)
4. Glomerulonephritis (P)
5. Oral cancer
6. RHD/IHD

Pharmacology

1. General aspects (adverse effect profile and resistance mechanisms) of antimicrobial agents
2. ATT
3. HAART (P)
4. Antidiabetic agents (P)
5. Beta-Lactam Antibiotics
6. Antihypertensive and Vasodilators
7. MOA/SE of Ketoconazole/Metronidazole/Chloroquine/Spironolactone/Aspirin/Vinka alkaloids

General Medicine

1. Uses of USG in medical diagnosis
2. Pharmacological management of anxiety and depressive disorders (P)
3. Acute Coronary Syndrome
4. Pulmonary embolism
5. Complications of Diabetes mellitus (P)
6. Meningitis (Cryptococcal, Meningococcal and Tuberculous)
7. Hyper and Hypothyroidism
8. Nephrotic syndrome
9. Cirrhosis of Liver
10. Dermatitis/Eczema
11. Steven Johnson syndrome (P)
12. Vitiligo
13. Psoriasis (P)
14. Lichen planus
15. Scabies

Pediatrics

1. Cyanotic CHD (P)
2. Neonatal jaundice
3. ARI protocol/Pneumonia (P)
4. Respiratory distress
5. Diarrhea management (P)
6. Severe acute malnutrition
7. IMNCI (P)
8. Breastfeeding

General Surgery

1. Breast carcinoma
2. Acute pancreatitis/cholecystitis (P)
3. Varicose veins
4. Thoracic injuries (P)
5. Tumors of thyroid (P)
6. Liver abscess
7. Renal stones/Gall stones (P)
8. Gall bladder and Bile ducts
9. Disorders of the Anus and Rectum
10. Bleeding peptic ulcer

OBG including family planning

1. Preeclampsia (P)
2. Antepartum hemorrhage
3. Anemia in pregnancy
4. Postpartum hemorrhage
5. Carcinoma cervix (P)
6. Menopause
7. IUCD/OC pills
8. Female sterilization
9. MTP ACT/Surrogacy bill (P)
10. Infertility work up (P)

PSM

1. National Kala-azar elimination program
2. National Framework for Malaria Elimination in INDIA (2016-2030)
3. PM TB Mukt Bharat Abhiyan (NIkhay Mitra) (P)
4. END YB strategy
5. POSHAN 2.0
6. Vandemataram Scheme
7. Laqshya program
8. JSY/JSSK/RSBK
9. Ayushman Bharat/Health and Wellness centers
10. Health-Related Sustainable Development Goals
11. Epidemic investigation
12. Biomedical waste management (P)
13. Maternal Mortality Rate and Infant mortality rate
14. LBW/Underweight

GREY ZONE TOPICS (Uncertain)

1. Cranial nerves : functional components
2. Peripheral Nerve injuries (Median, Radial and Ulnar Nerve)
3. Joints (Hip/Shoulder/Knee joint)
4. Tools of Biochemistry (RIA/PCR/RFLP)
5. Vitamins and minerals
6. Toxicology/Poisonings
7. Injuries (Forensic Medicine)
8. DNA/Finger print study
9. Immunoglobulins and Hypersensitivity reactions
10. Glomerulonephritis (Renal Pathology)
11. Antibiotics (Antimicrobial agents)
12. Diuretics/Antidiuretics
13. Imaging in medical problems
14. Complications of Diabetes mellitus
15. Complications of Cirrhosis of Liver
16. Meningitis
17. Malabsorption syndromes
18. Dermatitis
19. Cyanotic congenital heart diseases
20. Baby Friendly Hospital Initiative
21. IMNCI
22. Kernicterus
23. Management of surgical conditions of Rectum, Anus and Anal canal, Gall bladder and Bile ducts.
24. NRHM/MCH/Nutritional Programmes

UNASKED

1. SDG s
2. Vitiligo
3. Endoscopy
4. Stones of ureter and bladder
5. Cleft lip and palate
6. Coarctation of aorta
7. Neonatal resuscitation
8. 2D Echo
9. Antidiuretics
10. Anti KalaAzar
11. Antiviral
12. Antiparasitic
13. Coagulation disorders
14. Japanese Encephalitis
15. Giardia
16. Osteomyelitis
17. Tissue repair
18. Optic and auditory pathways
19. Gonads
20. Development of gut
21. Ventricles of Brain and CSF
22. Vitamin E